Enhancement ofin vitrocell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1[alpha]-MUC1 pathway

In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialyl...

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Bibliographic Details
Published inCancer letters Vol. 339; no. 1; p. 82
Main Authors Goudarzi, Houman, Iizasa, Hisashi, Furuhashi, Masako, Nakazawa, Seitaro, Nakane, Rie, Liang, Shanshan, Hida, Yasuhiro, Yanagihara, Kazuyoshi, Kubo, Takanori, Nakagawa, Koji, Kobayashi, Masanobu, Irimura, Tatsuro, Hamada, Jun-ichi
Format Journal Article
LanguageEnglish
Published Clare Elsevier Limited 01.10.2013
Subjects
Binding sites
Cancer
Cell cycle
Cell growth
Cloning
Genes
Hypoxia
Kinases
Medical prognosis
Metastasis
Mortality
Motility
Tumors
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Summary:In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.07.020