Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B^sub 6^, and vitamin B^sub 12^ intakes

• Published in: Tumor biology Vol. 35; no. 12; p. 11895
• Main Authors: Jiang-hua, Qiao, De-chuang, Jiao, Zhen-duo, Lu, Shu-de, Cui, Zhenzhen, Liu
• Format: Journal Article
• Language: English
• Published: London Springer Nature B.V 01.12.2014
• Subjects: Breast cancer; Genes; Polymorphism; Risk factors; Vitamin B; China
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-014-2456-1

We assessed the association between dietary intake of folate and the MTHFR genotype with breast cancer in a Chinese population, with additional analysis of the interactions of gene polymorphisms and dietary intake of folate, vitamin B^sub 6^, and vitamin B^sub 12^. A case-control study was performed, and 535 patients with newly diagnosed breast cancer and 673 controls were enrolled into this study. The MTHFR 667TT genotype (odds ratio (OR)=1.82, 95 % confidence interval (CI)=1.24-2.97) and T allele (OR 0=1.48, 95 % CI=1.15-1.78) were correlated with a moderately significant increased risk of breast cancer when compared with the CC genotype. Individuals carrying the MTR 2756GG genotype (OR=1.66, 95 % CI=1.16-2.56) and G allele (OR=1.42, 95 % CI=1.26-1.81) had a higher risk of breast cancer when compared with subjects with the AA genotype. The MTHFR 667 T allele and MTR 2756 G allele were associated with a higher risk of breast cancer in individuals with low folate intake, vitamin B^sub 6^, and vitamin B^sub 12^, but the association disappeared among subjects with moderate and high intake of folate, vitamin B^sub 6^, and vitamin B^sub 12^. This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B^sub 6^, and vitamin B^sub 12^ intakes influence these associations.[PUBLICATION ABSTRACT]