GW25-e0865 Cardiac Stem Cell Transplantation Improve Electrophysiological Stability in Rats with Myocardial Infarction via Inhibition of TGF-[beta]1 Pathway

Methods MI was induced in 30 male Sprague-Dawley rats. 2 weeks later, animals were randomized to receive 5x106 CSCs labeled with PKH26 in PBS, 5x106 MSCs labeled with PKH26 in phosphate buffer solution (PBS) or PBS alone injection into the infarcted anterior ventricular free wall (10 rats for each g...

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Published inJournal of the American College of Cardiology Vol. 64; no. 16; p. C6
Main Authors Shaoxin, Zheng, Tong, Wang, Jingying, Hou, Peifen, Liang, Yanling, Fang, Tianzhu, Guo, Jingfeng, Wang
Format Journal Article
LanguageEnglish
Published New York Elsevier Limited 21.10.2014
Subjects
Cardiology
Rodents
Stem cells
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Summary:Methods MI was induced in 30 male Sprague-Dawley rats. 2 weeks later, animals were randomized to receive 5x106 CSCs labeled with PKH26 in PBS, 5x106 MSCs labeled with PKH26 in phosphate buffer solution (PBS) or PBS alone injection into the infarcted anterior ventricular free wall (10 rats for each group). [...]we examined Transforming growth factor-β1 (TGF-β1) as well as its downstream signaling molecules in left ventricular tissues.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.06.037