Plasmodium falciparumsynthetic LbL microparticle vaccine elicits protective neutralizing antibody and parasite-specific cellular immune responses

Highlights * A synthetic microparticle vaccine elicits protection from malaria in mouse models. * The vaccine is made using the layer-by-layer (LbL) fabrication method. * The vaccine includes a peptide subunit of thePlasmodiumCS protein. * All components are chemically synthesized; no biological mat...

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Bibliographic Details
Published inVaccine Vol. 31; no. 15; p. 1898
Main Authors Powell, Thomas J, Tang, Jie, DeRome, Mary E, Mitchell, Robert A, Jacobs, Andrea, Deng, Yanhong, Palath, Naveen, Cardenas, Edwin, Boyd, James G, Nardin, Elizabeth
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 08.04.2013
Subjects
Atoms & subatomic particles
Disease
Fabrication
Malaria
Mortality
Parasites
Peptides
Proteins
Vaccines
Vector-borne diseases
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Summary:Highlights * A synthetic microparticle vaccine elicits protection from malaria in mouse models. * The vaccine is made using the layer-by-layer (LbL) fabrication method. * The vaccine includes a peptide subunit of thePlasmodiumCS protein. * All components are chemically synthesized; no biological materials are used.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.02.027