Intranasal immunisation of mice againstStreptococcus equiusing positively charged nanoparticulate carrier systems

Highlights * Positively charged nanoparticulate systems were compared as vaccine carriers. *S. equiantigens were incorporated in liposomes and chitosan nanoparticles. * Formulations were given i.n. to mice and elicited humoral and cellular responses. * Increased sIgA in lungs was obtained specially...

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Bibliographic Details
Published inVaccine Vol. 30; no. 46; p. 6551
Main Authors Figueiredo, L, Cadete, A, Gonçalves, LMD, Corvo, ML, Almeida, AJ
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 12.10.2012
Subjects
Cytokines
Horses
Immune system
Lymphatic system
Molecular weight
Nanoparticles
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Summary:Highlights * Positively charged nanoparticulate systems were compared as vaccine carriers. *S. equiantigens were incorporated in liposomes and chitosan nanoparticles. * Formulations were given i.n. to mice and elicited humoral and cellular responses. * Increased sIgA in lungs was obtained specially with mucoadhesive chitosan particles. * Both formulations induced Th1 and Th2 responses.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.08.050