Schistosoma japonicumcalcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice

Highlights * We cloned and characterized TP22.4, a novel tegumental protein inS. japonicum. * Circular dichroism measurement demonstrates SjTP22.4 has Ca2+binding ability. * TP22.4 immunization showed a decrease in liver pathology in challenge experiment. * SjTP22.4 combined with praziquantel showed...

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Bibliographic Details
Published inVaccine Vol. 30; no. 34; p. 5141
Main Authors Zhang, Zhaoping, Xu, Hongxu, Gan, Wenjia, Zeng, Suxiang, Hu, Xuchu
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 20.07.2012
Subjects
Antigens
Bioinformatics
Cattle
Cloning
Eggs
Immunization
Immunology
Infections
Liver
Molecular weight
Pathology
Proteins
China
Africa
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Summary:Highlights * We cloned and characterized TP22.4, a novel tegumental protein inS. japonicum. * Circular dichroism measurement demonstrates SjTP22.4 has Ca2+binding ability. * TP22.4 immunization showed a decrease in liver pathology in challenge experiment. * SjTP22.4 combined with praziquantel showed more significant protection. * SjTP22.4 with PZQ is of value in killing schistosomulum.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.05.056