Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined within situtumor destruction

Highlights * Various adjuvants are combined within situtumor destruction to generate anti-tumor immunity. * Only saponin-based adjuvants lead to a very potent anti-tumor immune response. * No prior structural knowledge of tumor antigens is required. * Saponins form attractive tools in settings where...

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Bibliographic Details
Published inVaccine Vol. 30; no. 4; p. 737
Main Authors den Brok, Martijn H, Nierkens, Stefan, Wagenaars, Jori A, Ruers, Theo J, Schrier, Carla C, Rijke, Eric O, Adema, Gosse J
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 17.01.2012
Subjects
Animal vaccines
Antigens
Cancer
Immune response
Immune system
Laboratories
Ligands
Lymphocytes
Melanoma
Metastasis
Tumors
Ultrasonic imaging
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Summary:Highlights * Various adjuvants are combined within situtumor destruction to generate anti-tumor immunity. * Only saponin-based adjuvants lead to a very potent anti-tumor immune response. * No prior structural knowledge of tumor antigens is required. * Saponins form attractive tools in settings wherein situtumor destruction is applied.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.11.080