Improved long-term protection againstMycobacterium tuberculosisBeijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens

• Published in: Vaccine Vol. 29; no. 47; p. 8740
• Main Authors: Reece, Stephen T, Nasser-Eddine, Ali, Dietrich, Jes, Stein, Maik, Zedler, Ulrike, Schommer-Leitner, Sandra, Ottenhoff, Tom HM, Andersen, Peter, Kaufmann, Stefan HE
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 03.11.2011
• Subjects: Bacteria; Cloning; Deoxyribonucleic acid; DNA; Genes; HIV; Human immunodeficiency virus; Hypoxia; Infections; Studies; Tuberculosis

Highlights * We show expression of latency-associated antigens by recombinant BCG improves longevity of protection against tuberculosis in a murine model. * This improved protection was achieved against a representative of the medically-relevant Beijing/W lineage ofMycobacterium tuberculosisstrains....