Improved long-term protection againstMycobacterium tuberculosisBeijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens

Highlights * We show expression of latency-associated antigens by recombinant BCG improves longevity of protection against tuberculosis in a murine model. * This improved protection was achieved against a representative of the medically-relevant Beijing/W lineage ofMycobacterium tuberculosisstrains....

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Bibliographic Details
Published inVaccine Vol. 29; no. 47; p. 8740
Main Authors Reece, Stephen T, Nasser-Eddine, Ali, Dietrich, Jes, Stein, Maik, Zedler, Ulrike, Schommer-Leitner, Sandra, Ottenhoff, Tom HM, Andersen, Peter, Kaufmann, Stefan HE
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 03.11.2011
Subjects
Bacteria
Cloning
Deoxyribonucleic acid
DNA
Genes
HIV
Human immunodeficiency virus
Hypoxia
Infections
Studies
Tuberculosis
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Summary:Highlights * We show expression of latency-associated antigens by recombinant BCG improves longevity of protection against tuberculosis in a murine model. * This improved protection was achieved against a representative of the medically-relevant Beijing/W lineage ofMycobacterium tuberculosisstrains. * This study provides a proof-of-principle that expression of latency-associated antigens by recombinant BCG can improve vaccine efficacy.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.07.144