Radical CH Functionalization of Heteroarenes under Electrochemical Control

Electrochemical reactions are shown to be effective for the CH functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the CH...

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Published inAngewandte Chemie Vol. 126; no. 44; p. 12062
Main Authors O'Brien, Alexander G, Maruyama, Akinobu, Inokuma, Yasuhide, Fujita, Makoto, Baran, Phil S, Blackmond, Donna G
Format Journal Article
LanguageGerman
Published Weinheim Wiley Subscription Services, Inc 27.10.2014
Subjects
Chemistry
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Summary:Electrochemical reactions are shown to be effective for the CH functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the CH functionalization of a series of heterocycles of interest in medicinal chemistry.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201407948