Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice

Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazone...

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Published inRevista da Sociedade Brasileira de Medicina Tropical Vol. 47; no. 4; p. 517
Main Authors Ana, Angélica Amorim Santarem, Gabriel, Frizon Greggianin, Rafaela, Garcia Debastiani, Jefferson, Bruno Pereira Ribeiro, Demerson, Andre Polli, Raimunda, Nonata Ribeiro Sampaio
Format Journal Article
LanguageEnglish
Published Rio de Janeiro Sociedade Brasileira de Medicina Tropical 01.07.2014
Subjects
Animal diseases
Cytokines
Parasitic diseases
Parasitic protozoa
Rodents
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Summary:Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.
ISSN:0037-8682
1678-9849
DOI:10.1590/0037-8682-0202-201