Association Between Single Nucleotide Polymorphisms of Sterol Regulatory Element Binding Protein-2 and Liver X Receptor [alpha] Gene and Risk of Polycystic Ovary Syndrome in a Chinese Han Population

• Published in: Cell biochemistry and biophysics Vol. 70; no. 2; p. 1421
• Main Authors: Zhao, Jianhong, Hu, Zhiying, Cai, Long, Liu, Ling, Jiang, Xijing, Wu, Linzhen, Gong, Junling
• Format: Journal Article
• Language: English
• Published: Totowa Springer Nature B.V 01.11.2014
• Subjects: Genotypes
• ISSN: 1085-9195; 1559-0283
• DOI: 10.1007/s12013-014-0075-5

To investigate associations of single nucleotide polymorphisms (SNPs) rs2228314 of sterol regulatory element-binding protein-2 (SREBP-2) or rs11039155 of liver X receptor [alpha] (LXR[alpha]) with susceptibility to polycystic ovary syndrome (PCOS) in a Chinese Han population. SREBP-2 rs2228314 and LXR[alpha] rs11039155 polymorphisms were genotyped in patients with PCOS and age- and sex-matched PCOS-free controls from a Chinese Han population. A total of 605 patients with PCOS and 615 controls were recruited in this study. We found that GC and CC genotypes of rs2228314, and variant C, were associated with a significantly increased risk of PCOS. In addition, GA and AA genotypes of rs11039155, as well as variant A, were also associated with a significantly increased risk of PCOS. Our results showed that SREBP-2 rs2228314 G to C change and variant C genotype as well as LXR[alpha] rs11039155 G to A change and variant A may contribute to PCOS in Chinese Han population.[PUBLICATION ABSTRACT]