Effect of egg yolk antibody on experimentalCryptosporidiumparvuminfection inscidmice

In this study the effect of chicken egg yolk antibody (IgY) againstCryptosporidium parvuminfection was examined. IgY sample was prepared from eggs of chickens immunized withC. parvumoocyst antigens. In vitro, antibody-treated sporozoites showed reduced binding to Caco-2 cells and lost vitality. Thes...

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Bibliographic Details
Published inVaccine Vol. 23; no. 2; p. 232
Main Authors Kobayashi, Chizu, Yokoyama, Hideaki, Nguyen, Sa van, Kodama, Yoshikatsu, Kimata, Tsutomu, Izeki, Motohiro
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 25.11.2004
Subjects
Antigens
Cattle industry
Cell culture
Chickens
Cryptosporidiosis
Cryptosporidium
Eggs
Feeds
Immunization
Infections
Medical research
Protozoa
Studies
Japan
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Summary:In this study the effect of chicken egg yolk antibody (IgY) againstCryptosporidium parvuminfection was examined. IgY sample was prepared from eggs of chickens immunized withC. parvumoocyst antigens. In vitro, antibody-treated sporozoites showed reduced binding to Caco-2 cells and lost vitality. These phenomena were not observed with a control IgY sample prepared from eggs of non-immunized chickens.Scidmice orally administered with the antibody demonstrated partial reduction in oocyst shedding after challenge with 103oocysts. IgY, however, could not eliminate the infection after 17 days of continuous treatment. The potentials of using specific IgY for treatment and prevention of cryptosporidiosis were discussed.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.05.034