Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeableHaemophilus influenzaeouter membrane protein

To determine the dynamics of dendritic cell (DCs) migration and their role in recurrent infections by nontypeableHaemophilus influenzae(NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were exam...

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Published inVaccine Vol. 24; no. 31-32; p. 5896
Main Authors Kurita, Shin-ichi, Koyama, Jun, Onizuka, Shozaburo, Motomura, Kazushi, Watanabe, Hiroshi, Watanabe, Kiwao, Senba, Masachika, Apicella, Michael A, Murphy, Timothy F, Yoneyama, Horoyuki, Matsushima, Kouji, Nagatake, Tsuyoshi, Oishi, Kazunori
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 26.07.2006
Subjects
Bacteria
Cell growth
Chemokines
Ear diseases
Immune response
Lymph nodes
Proteins
Rodents
Japan
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Summary:To determine the dynamics of dendritic cell (DCs) migration and their role in recurrent infections by nontypeableHaemophilus influenzae(NTHi), the migration of mature DC into pulmonary lymph nodes (LN) and the development of a P6-specific immune response and bacterial clearance in the lung were examined after repeated airway challenges with outer membrane protein (OMP) at 1-week intervals in mice. Although the migration of mature DC into the pulmonary LN is attenuated after repeated airway challenge with OMP, the in vitro P6-specific T cell proliferation in the cultured pulmonary LN cells was enhanced and was subsequently linked to the development of P6-specific IgA production and the development of protective immunity in the airway of mice.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.04.041