Kinetics of asthma- and allergy-associated immune response gene expression in peripheral blood mononuclear cells from vaccinated infants afterin vitrore-stimulation with vaccine antigen

The global expression of immune response genes in infants after vaccination and their role in asthma and allergy is not clearly understood. Pharmacogenomics is ideally suited to study the involved cellular responses, since the expression of thousands of genes can be assessed simultaneously. Here, ar...

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Bibliographic Details
Published inVaccine Vol. 26; no. 14; p. 1725
Main Authors Lahdenperä, Anne I, Nilsson, Lennart J, Regnström, Karin
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 25.03.2008
Subjects
Allergies
Asthma
Babies
Data mining
Experiments
Gene expression
Immune response
Immune system
Infants
Kinetics
Poliomyelitis
Public health
Software
Toxins
Vaccines
Whooping cough
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Summary:The global expression of immune response genes in infants after vaccination and their role in asthma and allergy is not clearly understood. Pharmacogenomics is ideally suited to study the involved cellular responses, since the expression of thousands of genes can be assessed simultaneously. Here, array technology was used to assess the expression kinetics of immune response genes with association to asthma and allergy in peripheral blood mononuclear cells (PBMC) of five healthy infants after vaccination with Infanrix-Polio+Hib. At 12h afterin vitrore-stimulation of the PBMC with pertussis toxin (PT) antigen, 14 immune response pathways, 33 allergy-related and 66 asthma-related genes were found activated.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.01.041