Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates withMRE11mutations and synergizes with platinums and irinotecan in colorectal cancer cells
Some colorectal cancers (CRC) display microsatellite instability (MSI) leading to mutations in genes such asMRE11. The aim of this study was to determine whether MSI orMRE11mutational status correlates with sensitivity to the PARP inhibitor LT-626 and whether LT-626 synergizes with DNA-damaging chem...
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Published in | Cancer letters Vol. 343; no. 2; p. 217 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Clare
Elsevier Limited
28.02.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Some colorectal cancers (CRC) display microsatellite instability (MSI) leading to mutations in genes such asMRE11. The aim of this study was to determine whether MSI orMRE11mutational status correlates with sensitivity to the PARP inhibitor LT-626 and whether LT-626 synergizes with DNA-damaging chemotherapeutic agents. CRC cells harboring biallelicMRE11mutations were more sensitive to LT-626 and stable overexpression or knock-down of MRE11 in cell lines correlated with sensitivity. Synergism was evident between LT-626 and cisplatin, oxaliplatin and SN-38 suggesting that PARP inhibitors in combination with DNA damaging agents may be a successful strategy for treatment of CRC. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2013.10.034 |