Attenuation of bovine herpesvirus type 1 by deletion of its glycoprotein G andtkgenes and protection against virulent viral challenge

Highlights * BoHV-1gG-/tk-mutant could stimulate cell mediated immunity and humoral immunity response. * The mutant could not be reactivated by dex injection. * It could provides a good level of protection.

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Bibliographic Details
Published inVaccine Vol. 29; no. 48; p. 8943
Main Authors Zhang, Minmin, Fu, Shulin, Deng, Mingliang, Xie, Qian, Xu, Haiyang, Liu, Zhengfei, Hu, Changmin, Chen, Huanchun, Guo, Aizhen
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 08.11.2011
Subjects
Cattle
Cloning
Gene expression
Genomes
Infections
Plasmids
Proteins
Vaccines
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Summary:Highlights * BoHV-1gG-/tk-mutant could stimulate cell mediated immunity and humoral immunity response. * The mutant could not be reactivated by dex injection. * It could provides a good level of protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.09.050