Group V Secretory PLA2Alternative Activation of Macrophages Contributes to Pulmonary Inflammation Induced by House Dust Mite

Group V secretory phospholipase A2 (sPLA2) regulates phagocytosis of pathogens by macrophages and processing of house dust mite allergens by dendritic cells. Because mice lacking group V sPLA2 showed markedly diminished pulmonary inflammation and Th2-polarized immune responses to an extract (Df) of...

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Published inJournal of allergy and clinical immunology Vol. 127; no. 2; p. AB270
Main Authors Balestrieri, B, Giannattasio, G, Fujioka, D, Ota, S, Katz, H, Boyce, JA
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Limited 01.02.2011
Subjects
Dust
Medical research
Rodents
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Summary:Group V secretory phospholipase A2 (sPLA2) regulates phagocytosis of pathogens by macrophages and processing of house dust mite allergens by dendritic cells. Because mice lacking group V sPLA2 showed markedly diminished pulmonary inflammation and Th2-polarized immune responses to an extract (Df) of house dust mite Dermatophagoides farinae, we evaluated the role of group V sPLA2 in alternative activation of macrophages, an important event in allergic pulmonary inflammation.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.1074