Specific antibodies induced by nasally administered 40-kDa outer membrane protein ofPorphyromonas gingivalisinhibits coaggregation activity ofP. gingivalis

In this study, we have assessed the efficacy of the 40-kDa outer membrane protein (40k-OMP) ofPorphyromonas gingivalisas a nasal vaccine for the prevention of adult periodontitis. Mice nasally immunized with 40k-OMP and cholera toxin as mucosal adjuvant displayed significant levels of 40k-OMP-specif...

Full description

Saved in:
Bibliographic Details
Published inVaccine Vol. 22; no. 2; p. 250
Main Authors Namikoshi, Jun, Otake, Shigeo, Maeba, Satomi, Hayakawa, Mitsuo, Abiko, Yoshimitsu, Yamamoto, Masafumi
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 12.12.2003
Subjects
Antigens
Bacteria
Bacteriology
Disease
Disease prevention
Gram-positive bacteria
Immunization
Prevention
Proteins
Studies
Toxins
Waterborne diseases
Online AccessGet full text

Cover

More Information
Summary:In this study, we have assessed the efficacy of the 40-kDa outer membrane protein (40k-OMP) ofPorphyromonas gingivalisas a nasal vaccine for the prevention of adult periodontitis. Mice nasally immunized with 40k-OMP and cholera toxin as mucosal adjuvant displayed significant levels of 40k-OMP-specific serum IgG1, IgG2b and IgA as well as mucosal IgA antibodies (Abs) in saliva and nasal secretions. Ab-forming cell (AFC) analysis confirmed the antibody titers by detecting high numbers of 40k-OMP-specific AFCs in spleen, salivary glands and nasal passages. Because 40k-OMP-specific IgG inhibited coaggregation ofP. gingivalisvesicles andS. gordonii, it may be an important tool for the prevention of adult periodontitis.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00576-0