Protective immunity against pasteurellosis in cattle, induced byPasteurella haemolyticaghosts

Pasteurella haemolyticais a cattle pathogen of significant economic impact. An effective vaccine against bovine pneumonic pasteurellosis is therefore of high importance. Apart from economic concerns, pasteurellosis caused byP. haemolyticais a serious disease leading to death in cattle if it remains...

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Bibliographic Details
Published inVaccine Vol. 21; no. 13-14; p. 1415
Main Authors Marchart, J, Rehagen, M, Dropmann, G, Szostak, MP, Alldinger, S, Lechleitner, S, Schlapp, T, Resch, S, Lubitz, W
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Limited 28.03.2003
Subjects
Antigens
Bacteria
Cattle
Deoxyribonucleic acid
DNA
E coli
Economic impact
Economics
Fermentation
Gene expression
Gram-negative bacteria
Immunization
Infections
Plasmids
Studies
Vaccines
United Kingdom > UK
United States > US
California
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Summary:Pasteurella haemolyticais a cattle pathogen of significant economic impact. An effective vaccine against bovine pneumonic pasteurellosis is therefore of high importance. Apart from economic concerns, pasteurellosis caused byP. haemolyticais a serious disease leading to death in cattle if it remains untreated. In this studyP. haemolytica--ghosts are presented as a promising vaccine candidate in cattle. To obtain sufficient vaccination material a fermentation protocol forP. haemolytica--ghost production was established. With the obtained experimentalP. haemolytica--ghost vaccine, cattle immunization studies were performed based on aPasteurellacattle challenge model developed specifically for vaccine validation. It was shown that protective immunization of cattle against homologous challenge was induced by adjuvantedP. haemolytica--ghosts. The level of protection was similar to a commercially available vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(02)00635-7