EFFECT OF THE C^sub 60^ FULLERENE, DOXORUBICIN AND THEIR COMPLEX ON CANCER AND NORMAL CELLS OF BALB/c MICE

One of the main strategies in anticancer therapy is inhibition of the proliferative activity of cancer cells. However, antitumor action of conventional chemotherapy is always associated with numerous side effects; in particular, its toxic with respect to normal organs and in many cases promotes the...

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Published inBiotechnologia acta Vol. 7; no. 1; p. 60
Main Authors Prylutska, S V, Didenko, G V, Kichmarenko, Yu M, Kruts, O O, Potebnya, G P, Cherepanov, V V, Prylutskyy, Yu I
Format Journal Article
LanguageEnglish
Published Kyiv Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine 01.01.2014
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Summary:One of the main strategies in anticancer therapy is inhibition of the proliferative activity of cancer cells. However, antitumor action of conventional chemotherapy is always associated with numerous side effects; in particular, its toxic with respect to normal organs and in many cases promotes the progression of tumors. In this regard, there is a need to develop alternative therapies of tumors and the search of new non/low toxic (relative to normal cells) tumoritropic substances, which cause their degradation. The toxic effects of these substances on cancer cells can be realized by stimulating their death due to necrosis or apoptosis. The toxic effect of the created pristine C60 fullerene with an antibiotic anthracyclines doxorubicin (Dox) complex on tumor (Ehrlich ascites carcinoma) and immune (lymphocytes and macrophages) cells and hepatocytes was evaluated. It demonstrates the potential for high efficiency of C60+Dox complex use in cancer therapy.
ISSN:1995-5537