Germline variations of the topoisomerase II[alpha] gene as risk factors for primary gastric B-cell lymphoma

• Published in: Cancer letters Vol. 238; no. 2; p. 295
• Main Authors: Hellmig, Stephan, Gieseler, Frank, Ott, Stephan, Rosenstiel, Phillip, Fischbach, Wolfgang, Fölsch, Ulrich Robert, Schreiber, Stefan
• Format: Journal Article
• Language: English
• Published: Clare Elsevier Limited 18.07.2006
• Subjects: Genes; Infections; Lymphoma; Mutation

We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronicHelicobacter pyloriinfection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associati...