Germline variations of the topoisomerase II[alpha] gene as risk factors for primary gastric B-cell lymphoma

We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronicHelicobacter pyloriinfection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associati...

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Bibliographic Details
Published inCancer letters Vol. 238; no. 2; p. 295
Main Authors Hellmig, Stephan, Gieseler, Frank, Ott, Stephan, Rosenstiel, Phillip, Fischbach, Wolfgang, Fölsch, Ulrich Robert, Schreiber, Stefan
Format Journal Article
LanguageEnglish
Published Clare Elsevier Limited 18.07.2006
Subjects
Genes
Infections
Lymphoma
Mutation
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Summary:We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronicHelicobacter pyloriinfection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.05). No genetic variations in the promotor region were found in 92 chromosomes of lymphoma patients and controls and linkage disequilibrium indicated a highly conserved genomic region. The results of our work exclude genetic variations as predisposing factors of primary gastric B-cell lymphoma development.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.07.017