Restriction Endonuclease Analysis of Bovine Herpesvirus Type 1 Isolates from Calves with Fatal Encephalitis

Meningo-encephalitis in feedlot cattle sporadically occurred in the Tokachi area in northern Japan. The calves had been vaccinated intranasally with a mixed live-vaccine (infectious bovine rhinotracheitis virus, bovine viral diarrhea-mucosal disease virus, and parainfluenza 3 virus) for which intram...

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Published inJournal of veterinary medical science Vol. 57; no. 3; p. 577
Main Authors HORIUCHI, Motohiro, YAMAZAKI, Noriko, FURUOKA, Hidefumi, MATSUI, Takane, NAKAGAWA, Michio, ISHIGURO, Naotaka, SHINAGAWA, Morikazu
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.05.1995
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Summary:Meningo-encephalitis in feedlot cattle sporadically occurred in the Tokachi area in northern Japan. The calves had been vaccinated intranasally with a mixed live-vaccine (infectious bovine rhinotracheitis virus, bovine viral diarrhea-mucosal disease virus, and parainfluenza 3 virus) for which intramuscular inoculation was indicated. Two additional live vaccines, bovine adenovirus type 7 and bovine respiratory syncytical vilus, had been inoculated simultaneously. Eleven isolates of bovine herpesvirus type 1 were plaque-purified from two brains with fatal encephalitis; their viral DNAs were examined by restriction endonuclease analysis (REA) using PstI and HindIII. The REA patterns of the virus clones were almost identical to those of the vaccine strain 758-43, suggesting that the isolates from this outbreak of fatal encephalitis originated in the abnormally administrated vaccine.
ISSN:0916-7250
1347-7439