Water Mediation Is Essential to Nucleation of [beta]-Turn Formation in Peptide Folding Motifs

Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a [beta]-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, i...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 52; no. 49; p. 13091
Main Authors Busch, Sebastian, Bruce, Chrystal D, Redfield, Christina, Lorenz, Christian D, McLain, Sylvia E
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 02.12.2013
EditionInternational ed. in English
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Summary:Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a [beta]-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201307657