2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers

Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylen...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 59; no. 4; p. 472
Main Authors Ishikawa, Tsutomu, Saito, Tatsuru, Kurosawa, Ayako, Watanabe, Toshiko, Maruyama, Sakiko, Ichikawa, Yuh-ichiro, Yamada, Ryota, Okuzawa, Hiroko, Sato, Hiromi, Ueno, Koichi
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.04.2011
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Summary:Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti-cancer drugs.
ISSN:0009-2363
1347-5223