Formation of 17[beta]-Alkoxy-16-keto Steroids by Reaction of 16[alpha]-Hydroxy-17-keto and 17[beta]-Hydroxy-16-keto Steroids with Trimethylsilyl Iodide in the Presence of Alkyl Alcohols

16α-Hydroxy-17-keto steroids, 1, 3, and 8, and their 17β-hydroxy-16-keto isomers, 4, 5, and 9, were transformed into the corresponding 17β-alkoxy-16-keto derivatives on treatment with trimethylsilyl iodide (TMSI) in the presence of alkyl alcohol in CHCl3 in poor to high yields.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 48; no. 8; p. 1215
Main Authors NAGAOKA, Masao, ENDO, Michiko, NUMAZAWA, Mitsuteru
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.08.2000
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Summary:16α-Hydroxy-17-keto steroids, 1, 3, and 8, and their 17β-hydroxy-16-keto isomers, 4, 5, and 9, were transformed into the corresponding 17β-alkoxy-16-keto derivatives on treatment with trimethylsilyl iodide (TMSI) in the presence of alkyl alcohol in CHCl3 in poor to high yields.
ISSN:0009-2363
1347-5223