2-Arylmethyl-1, 4-benzoquinones. II. Novel Inhibitors of Platelet Aggregation

Two new series of 2-arylmethyl-1, 4-benzoquinones (2 and 3) were synthesized for evaluation of their pharmacological activities. These compounds showed significant inhibition of platelet aggregation and some of them possessed a protective effect against endothelial cell injury. Structure-activity re...

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Published inChemical & pharmaceutical bulletin Vol. 45; no. 4; p. 668
Main Authors SUZUKI, Kenji, TATSUOKA, Toshio, ISHIHARA, Takafumi, OGINO, Ryoko, MIYAZAKI, Tomoko, SATOH, Fumio, MIYANO, Seiji, SUMOTO, Kunihiro
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.04.1997
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Summary:Two new series of 2-arylmethyl-1, 4-benzoquinones (2 and 3) were synthesized for evaluation of their pharmacological activities. These compounds showed significant inhibition of platelet aggregation and some of them possessed a protective effect against endothelial cell injury. Structure-activity relationship studies indicated that 2b, 2d and 3b are potent inhibitors of platelet aggregation induced by arachidonic acid (AA) with an IC50 in the range of 1-10 μg/ml. Among them, 3b showed a significant inhibitory activity against endothelial cell injury caused by hydrogen peroxide (H2O2) at 1 μM.
ISSN:0009-2363
1347-5223