NON-ENZYMIC AND ENZYMIC OXYGENATIONS OF A DIBENZOCYCLOOCTADIENE LIGNAN, (±)-DEOXYSCHIZANDRIN

Non-enzimic and enzymic oxygenation reactions of (±)-dibenzocyclooctadiene lignan, (±)-deoxyschizandrin (1) using a simple model system for mono-oxygenases Fe(MeCN)62+-Ac2O-H2O2 and rat liver S9 mix were investigated in connection with mammalian and plant metabolisms of the corresponding lignans. Th...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 42; no. 8; p. 1694
Main Authors TAKEYA, Tetsuya, NAKAGAWA, Mitsuo, OHGUCHI, Akira, TOBINAGA, Seisho
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.08.1994
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Summary:Non-enzimic and enzymic oxygenation reactions of (±)-dibenzocyclooctadiene lignan, (±)-deoxyschizandrin (1) using a simple model system for mono-oxygenases Fe(MeCN)62+-Ac2O-H2O2 and rat liver S9 mix were investigated in connection with mammalian and plant metabolisms of the corresponding lignans. The non-enzymic reaction of 1 gave the two phenol acetates 4a and 5a and a quinone 6, and the enzymic reaction of 1 afforded several compounds from which three compounds characterized as 7, 8, and 9 were isolated. The latter result has implications for biosynthesis of these lignans.
ISSN:0009-2363
1347-5223