Synthesis and Immunological Effects of Thymosin [alpha]1 and Its Fragments on Inhibitory Factor in Minimal Change Nephrotic Syndrome

The octacosapeptide corresponding to the entire amino acid sequence of thymosin α1 was synthesized using the catalytic hydrogenation procedure at the final deprotection step. The depressed E-rosette forming capacity of lymphocytes caused by a serum factor from a patient in the active stage of MCNS w...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 28; no. 12; p. 3542
Main Authors ABIKO, TAKASHI, ONODERA, IKUKO, SEKINO, HIROSHI
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.12.1980
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Summary:The octacosapeptide corresponding to the entire amino acid sequence of thymosin α1 was synthesized using the catalytic hydrogenation procedure at the final deprotection step. The depressed E-rosette forming capacity of lymphocytes caused by a serum factor from a patient in the active stage of MCNS was significantly restored when the lymphocytes were incubated with thymosin α1. The relative potency of the decapeptide fragment (positions 19-28) was 1.04 and that of the pentadecapeptide fragment (positions 14-28) was 9.83 based on synthetic thymosin α1 (100.00) as a standard.
ISSN:0009-2363
1347-5223