Inhibitory Effects of Pasuchaca (Geranium dielsiaum) Extract on [alpha]-Glucosidase in Mouse
The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activi...
Saved in:
Published in | Bioscience, biotechnology, and biochemistry Vol. 70; no. 6; p. 1482 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
Oxford University Press
01.06.2006
|
Online Access | Get full text |
Cover
Loading…
Summary: | The methanolic extract of pasuchaca (Geranium dielsiaum) (PsEx) was found to suppress blood glucose elevation after oral administration of sucrose, maltose, and starch, but not after oral administration of glucose, in the mouse. In vitro examination of the inhibitory effect of PsEx on maltase activity revealed that PsEx strongly inhibited mouse small intestine maltase activity. Taken together, these results suggest that the inhibitory effect of PsEx on α-glucosidase activity might contribute to delay in carbohydrate digestion and subsequent lowering of the blood glucose level, thereby leading to prevention and cure of diabetes. |
---|---|
ISSN: | 0916-8451 1347-6947 |