Boosting the suppressive effects of Ascaris suum components in IFN-[gamma]-deficient mice

High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hype...

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Bibliographic Details
Published inRevista da Sociedade Brasileira de Medicina Tropical Vol. 42; no. 3
Main Authors Souza, Valdênia Maria Oliveira, Macedo, Mahasti Sahihi
Format Journal Article
LanguageEnglish
Published Rio de Janeiro Sociedade Brasileira de Medicina Tropical 01.05.2009
Subjects
Hypersensitivity
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Summary:High molecular weight components from Ascaris suum extract suppress ovalbumin-specific immunity in mice. In IFN-γ-deficient mice, ovalbumin-specific delayed-type hypersensitivity reactions are more strongly downregulated by these suppressive components. Here, the cellularity of the delayed-type hypersensitivity reaction in IFN-γ-deficient mice and the increased downregulation induced by Ascaris suum components were analyzed. IL-12p40-dependent neutrophilic influx was predominant. Suboptimal doses of the suppressive fraction from this nematode completely inhibited the hypersensitivity reaction, thus indicating intensification of the immunosuppression under conditions of intense recruitment of IFN-γ-independent neutrophils.
ISSN:0037-8682
1678-9849
DOI:10.1590/S0037-86822009000300021