Gene Polymorphisms of TNF-[alpha] and IL-1[Beta] Are Not Associated with Generalized Aggressive Periodontitis in an Iranian Subpopulation

• Published in: Iranian journal of allergy, asthma, and immunology Vol. 12; no. 4; p. 345
• Main Authors: Ebadian, Ahmad Reza, Radvar, Mehrdad, Afshari, Jalil Tavakkol, Sargolzaee, Naser, Brook, Azam, Ganjali, Rashiin, Tamizi, Mahmood, Arab, Hamid Reza
• Format: Journal Article
• Language: English
• Published: Tehran Tehran University of Medical Sciences 01.12.2013
• Subjects: Disease; Enzymes; Genes; Pathogenesis; Population; Studies; Iran
• ISSN: 1735-1502; 1735-5249

Cytokines play a part in pathogenesis of periodontitis via inflammation phenomenon. Aggressive periodontitis (AgP) is a multifactorial disease resulting in rapid tooth loss due to severe destruction of tooth supporting apparatus. Recently, researchers have focused on genetic susceptibility of periodontitis through investigating the gene variations of cytokines and other components of immune response. In this study, the authors have analyzed single nucleotide polymorphism (SNP) of two cytokines in association with AgP in an Iranian-Khorasani population; Interleukin-1 beta (IL-1β) +3954 C/T and Tumor Necrosis Factor alpha (TNF-α) -308 G/A. The frequency of genotypes and alleles had no significant differences between patients and control groups. The distributions were as follows. IL-1β +3954: CT, CC and TT genotypes in patients were 39.6%, 60.4% and 0.0% and in controls were 41.7%, 50% and 8.3%, respectively. TNF-α -308: GA, GG and AA genotypes in patients were 44.8%, 41.4% and 13.8% and in controls were 46.7%, 50% and 3.3%, respectively.