Calcium oxide nanoparticles catalyzed one-step multicomponent synthesis of highly substituted pyridines in aqueous ethanol media

An efficient one-pot three-component condensation of aldehydes, thiols and malononitrile has been developed in the presence of calcium oxide nanoparticles. Highly substituted pyridines as privileged medicinal scaffolds have been efficiently prepared via carbon-carbon and carbon-heteroatom bond forma...

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Bibliographic Details
Published inScientia Iranica. Transaction C, Chemistry, chemical engineering Vol. 20; no. 3; p. 549
Main Authors Safaei-Ghomi, J, Ghasemzadeh, M A, Mehrabi, M
Format Journal Article
LanguageEnglish
Published Tehran Sharif University of Technology 01.06.2013
Subjects
Catalysts
Chemical bonds
Chemical synthesis
Ethanol
Nanoparticles
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Summary:An efficient one-pot three-component condensation of aldehydes, thiols and malononitrile has been developed in the presence of calcium oxide nanoparticles. Highly substituted pyridines as privileged medicinal scaffolds have been efficiently prepared via carbon-carbon and carbon-heteroatom bond formation.Thismethod providesanovelandimprovedapproachfor thesynthesis of2-amino-4-aryl- 3,5-dicyano-6-sulfanylpyridines in terms of excellent yields, short reaction times, reusability and little catalyst loading. [PUBLICATION ABSTRACT]