The Mysteries of Chromosome Evolution in Gibbons: Methylation Is a Prime Suspect e1000501
The view that has emerged over the last decade, with a sharp acceleration since the publication of the human genome sequence, is of a fluid genomic landscape that is dotted with evidence of both large- and fine-scale chromosome rearrangements. [...]many of the gibbon breakpoints do not carry a signa...
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| Published in | PLoS genetics Vol. 5; no. 6 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
San Francisco
Public Library of Science
01.06.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The view that has emerged over the last decade, with a sharp acceleration since the publication of the human genome sequence, is of a fluid genomic landscape that is dotted with evidence of both large- and fine-scale chromosome rearrangements. [...]many of the gibbon breakpoints do not carry a signature (such as microhomology or Alu-Alu recombination events) that easily implicates any particular mechanism of rearrangement. [...]it is intriguing to consider the possibility that the epigenetic state of specific elements may have been disrupted at some point during the evolution of this gibbon species, which in turn increased the frequency for such elements to participate in rearrangement. |
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| AbstractList | The view that has emerged over the last decade, with a sharp acceleration since the publication of the human genome sequence, is of a fluid genomic landscape that is dotted with evidence of both large- and fine-scale chromosome rearrangements. [...]many of the gibbon breakpoints do not carry a signature (such as microhomology or Alu-Alu recombination events) that easily implicates any particular mechanism of rearrangement. [...]it is intriguing to consider the possibility that the epigenetic state of specific elements may have been disrupted at some point during the evolution of this gibbon species, which in turn increased the frequency for such elements to participate in rearrangement. |
| Author | Brown, Judith D |
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| Copyright | 2009 Brown, O'Neill. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Brown JD, O'Neill RJ (2009) The Mysteries of Chromosome Evolution in Gibbons: Methylation Is a Prime Suspect. PLoS Genet 5(6): e1000501. doi:10.1371/journal.pgen.1000501 |
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| DOI | 10.1371/journal.pgen.1000501 |
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| Title | The Mysteries of Chromosome Evolution in Gibbons: Methylation Is a Prime Suspect |
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