The Mysteries of Chromosome Evolution in Gibbons: Methylation Is a Prime Suspect e1000501

The view that has emerged over the last decade, with a sharp acceleration since the publication of the human genome sequence, is of a fluid genomic landscape that is dotted with evidence of both large- and fine-scale chromosome rearrangements. [...]many of the gibbon breakpoints do not carry a signa...

Full description

Saved in:
Bibliographic Details
Published inPLoS genetics Vol. 5; no. 6
Main Author Brown, Judith D
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 01.06.2009
Subjects
Deoxyribonucleic acid
DNA
DNA methylation
Evolution
Genetics
Genomics
Online AccessGet full text

Cover

More Information
Summary:The view that has emerged over the last decade, with a sharp acceleration since the publication of the human genome sequence, is of a fluid genomic landscape that is dotted with evidence of both large- and fine-scale chromosome rearrangements. [...]many of the gibbon breakpoints do not carry a signature (such as microhomology or Alu-Alu recombination events) that easily implicates any particular mechanism of rearrangement. [...]it is intriguing to consider the possibility that the epigenetic state of specific elements may have been disrupted at some point during the evolution of this gibbon species, which in turn increased the frequency for such elements to participate in rearrangement.
ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1000501