Effect of the [gamma]-aminobytyric acid derivative TZ-50-2 on systemic and cardiac hemodynamics and size of myocardial necrosis

The linear derivative of γ-aminobutyric acid TZ-50-2 (4-hydroxy-3-benzylamino-N-benzyl-butanamide hemisuccinate) stimulates coronary circulation (particularly in the left ventricular myocardium) in intact cats, decreases vascular resistance, stimulates the blood flow in ischemic endo- and mesocardiu...

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Published inBulletin of experimental biology and medicine Vol. 126; no. 6; p. 1231
Main Authors Galenko-yaroshevskii, P A, Medvedev, O S, Uvarov, A V, Mingalev, A N, Turovaya, A Yu, Tyukhteneva, Z I
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.12.1998
Subjects
Drug therapy
Heart attacks
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Summary:The linear derivative of γ-aminobutyric acid TZ-50-2 (4-hydroxy-3-benzylamino-N-benzyl-butanamide hemisuccinate) stimulates coronary circulation (particularly in the left ventricular myocardium) in intact cats, decreases vascular resistance, stimulates the blood flow in ischemic endo- and mesocardium, and decreases (similarly as perlinganite, obsidan, and finoptin) the necrotic zone area in experimental myocardial infarction.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02447160