Cardioprotective effects of T3-146, a cyclic derivative of [gamma]-aminobutyric acid, under conditions of reperfusion

Intravenous injection of T3-146, a cyclic derivative of γ-aminobutyric acid (structural analog of piracetam), 5 min prior to reperfusion of the descendent branch of the left coronary artery prevents the development of serious rhythm disturbances and stabilizes hemodynamics and cardiac function. Thes...

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Published inBulletin of experimental biology and medicine Vol. 124; no. 5; p. 1091
Main Authors Galenko-yaroshevskii, P A, Kryzhanovskii, S A, Uvarov, A V, Turovaya, A Yu, Popov, P B, Khankoeva, A I
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.11.1997
Subjects
Heart
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Summary:Intravenous injection of T3-146, a cyclic derivative of γ-aminobutyric acid (structural analog of piracetam), 5 min prior to reperfusion of the descendent branch of the left coronary artery prevents the development of serious rhythm disturbances and stabilizes hemodynamics and cardiac function. These effects are probably due to the inhibitory effect of this compound on lipid peroxidation in the myocardium.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445670