Regulation of Mitochondria Oxidative Metabolism by Tumor Suppressor FLCN

Birt-Hogg-Dube (BHD) syndrome is a hereditary hamartoma syndrome that predisposes patients to develop hair follicle tumors, lung cysts, and kidney cancer. Genetic studies of BHD patients have uncovered the causative gene, FLCN, but its function is incompletely understood. Here, Hasumi et al conduct...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 104; no. 22; p. 1750
Main Authors Hasumi, Hisashi, Baba, Masaya, Hasumi, Yukiko, Huang, Ying, Oh, Hyoungbin, Hughes, Robert M, Klein, Mara E, Takikita, Shoichi, Nagashima, Kunio, Schmidt, Laura S, Linehan, W Marston
Format Journal Article
LanguageEnglish
Published Oxford Oxford Publishing Limited (England) 21.11.2012
Subjects
Genes
Metabolism
Patients
Risk factors
Studies
Tumors
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Summary:Birt-Hogg-Dube (BHD) syndrome is a hereditary hamartoma syndrome that predisposes patients to develop hair follicle tumors, lung cysts, and kidney cancer. Genetic studies of BHD patients have uncovered the causative gene, FLCN, but its function is incompletely understood. Here, Hasumi et al conduct metabolic assays using FLCN-deficient muscle.
ISSN:0027-8874
1460-2105