Evaluation of antimalarial potential of aqueous stem bark extract of Bombax buonopozense P. Beauv. (Bombacaceae)

The treatment of malaria in Africa is becoming increasingly difficult due to rising prevalence of plasmodium falciparum resistant to antimalarial drugs. This study was undertaken to investigate the in vivo antiplasmodial effect of the aqueous stem bark extract of Bombax buonopozense in mice infected...

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Bibliographic Details
Published inEastern journal of medicine Vol. 17; no. 2; p. 72
Main Authors Iwuanyanwu, Tom Chinyere, Akuodor, Godwin Christian, Essien, Augustine Dick, Nwinyi, Florence Chidume, Akpan, Joseph Linus, Okora, Dorcas Okayo, Osunkwo, Uche Alex
Format Journal Article
LanguageEnglish
Published Van YYU Tip Fakultesi 01.04.2012
Subjects
Drug dosages
Laboratory animals
Malaria
Parasites
Pharmaceuticals
Phytochemicals
Ghana
Nigeria
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Summary:The treatment of malaria in Africa is becoming increasingly difficult due to rising prevalence of plasmodium falciparum resistant to antimalarial drugs. This study was undertaken to investigate the in vivo antiplasmodial effect of the aqueous stem bark extract of Bombax buonopozense in mice infected with chloroquinesensitive plasmodium berghei NK65. The in vivo antiplasmodial effect against early infection and curative effect against established infection were studied. The extract at all doses (100, 200 and 400 mg/kg, p.o.) used, exhibited significant (P<0.05), dose-dependent activity against the parasite in suppressive and curative tests. These results show that the stem bark extract of Bombax buonopozense plant has significant antiplasmodial effect. The reduction in parasitemia levels in the two employed models suggest that a part of its antimalarial activity is mediated by direct plasmocidal effect on the parasite. [PUBLICATION ABSTRACT]
ISSN:1301-0883
1309-3886