Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing [gamma][delta] cells

IL-17-producing CD27... cells (... cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-...-producing ... cells are poorly elucidated. Moreover, although human IL-17-producing ... cells are c...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 109; no. 43; p. 17549
Main Authors Michel, Marie-Laure, Pang, Dick J, Haque, Syeda FY, Potocnik, Alexandre J, Pennington, Daniel J, Hayday, Adrian C
Format Journal Article
LanguageEnglish
Published Washington National Academy of Sciences 23.10.2012
Subjects
Cell growth
Cells
Cytokines
Immunity (Disease)
Lymphocytes
T cell receptors
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Summary:IL-17-producing CD27... cells (... cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-...-producing ... cells are poorly elucidated. Moreover, although human IL-17-producing ... cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine ... T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17-producing ... cells to TCR agonists, thus reemphasizing the cells' adaptive and innate potentials. Moreover, human IL-17-producing ... cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17-producing ... cells, with both biological and clinical implications. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0027-8424
1091-6490