Synthesis of potentially bioactive PABA-related N-(aminoalkyl)lactamic amino acids and esters via selective S^sub N^Ar reactions
Issue Title: Peptides as Toxins/Defensins Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by S^sub N^Ar reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-...
Saved in:
Published in | Amino acids Vol. 40; no. 1; p. 197 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Vienna
Springer Nature B.V
01.01.2011
|
Online Access | Get full text |
Cover
Loading…
Summary: | Issue Title: Peptides as Toxins/Defensins Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by S^sub N^Ar reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition-elimination S^sub N^Ar mechanism was confirmed by NMR and MS measurements.[PUBLICATION ABSTRACT] |
---|---|
ISSN: | 0939-4451 1438-2199 |
DOI: | 10.1007/s00726-010-0634-z |