Highly concordant coexpression of aromatase and estrogen receptor [beta] in non-small cell lung cancer

• Published in: Human pathology Vol. 41; no. 2; p. 190
• Main Authors: Abe, Keiko, Miki, Yasuhiro, Ono, Katsuhiko, Mori, Miki, Kakinuma, Hideaki, Kou, Yuki, Kudo, Nobutaka, Koguchi, Masashi, Niikawa, Hiromichi, Suzuki, Satoshi, Evans, Dean B, Sugawara, Shunichi, Suzuki, Takashi, Sasano, Hironobu
• Format: Journal Article
• Language: English
• Published: Philadelphia Elsevier Limited 01.02.2010
• Subjects: Breast cancer; Cloning; Estrogens; Lung cancer; Statistical analysis; Studies; Womens health; Japan
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/j.humpath.2009.07.010

Estrogen receptor expression has been reported in non-small cell lung cancer. We examined the correlation between aromatase, a key enzyme in the synthesis of estrogen, and estrogen receptor expressions in 105 non-small cell lung cancer cases. All patients were older than 60 years, and all female patients were postmenopausal. Estrogen receptor α and progesterone receptor were detected in only 1 and 14 cases, respectively. Estrogen receptor β and aromatase were positive in 75 and 89 cases respectively. Estrogen receptor β expression in non-small cell lung cancer showed an inverse correlation with lymph node metastasis ( P < .05). Only among females, both estrogen receptor β and aromatase expressions were correlated with higher Ki-67 labeling index and younger age (P < .05). Among 89 aromatase-positive cases, 70 were positive for estrogen receptor β, demonstrating a significant concordance (P < .05). Simultaneous immunohistochemical staining for aromatase and estrogen receptor β showed a high rate of double positive association. Male non-small cell lung cancer cases with double positivity for aromatase and estrogen receptor β demonstrated lower status in N factor by TNM classification ( P < .05). In addition, among 89 aromatase-positive cases, a low-Allred total score of estrogen receptor β showed a significant relationship with large tumor size and high T factor by TNM classification (P < .05). In conclusion, frequent coexpression of aromatase and estrogen receptor β in non-small cell lung cancer might suggest some functional correlation between aromatase and estrogen receptor β, whereas estrogen receptor β negativity might be correlated with malignant progression of non-small cell lung cancer.