The assessment of the angiogenesis in the uterine cervix carcinogenesis

• Published in: Journal of Experimental and Molecular Biology Vol. 9; no. 2
• Main Authors: Francu, Doina Lucia, Francu, LAURIAN LUCIAN, Crauciuc, Eduard, Pandeli, Radu, Loreta, Cozma, Calin, DORELIA LUCIA, Toma, Ovidiu
• Format: Journal Article
• Language: English
• Published: Iasi Universitatea "Alexandru Ioan Cuza" 01.05.2008
• ISSN: 2601-6974; 2601-6974

The uterine carcinoma represents one of the most frequent malignant tumors in female. Great progresses weremade in the understanding of the mechanisms of the appearance and evolution of the tumors, and also in the earlydiagnosis of them. In the present time, the discussions are centered on the angiogenesis and the neovascularisation.During the researches regarding the new factors of prognosis in cervical carcinomas, we are interesting firstly in the studyof neoangiogenesis and its predictive role. The microanatomic quantitative study was made on fragments which wereprocessed from uterine cervix dysplasias, preinvasive and invasive tumors. The sections were stained specificimmunohistochemically (CD34) and examined with an interactive digital program. We have quantified the density of themicrovessels/mm2 tumor stroma and the density of the microvessels/mm2 tumor. The preliminary results regarding thestudy of the microvessels in uterine cervix carcinomas show a positive correlation between the density and the evolutionof the tumor, the angiogenetic process rises simultaneously with the risk of metastasis. This study shows a significantcorrelation between the density of vessels and the evolution of the uterine cervix carcinomas, the appearance ofrecurrences and metastasis. The quantification of the angiogenesis is an indicator with an high degree of precision, with isused for the detection of the aggressiveness and malignancy of the uterine cervix tumors.