Correlation between TCRC[alpha] -560 C/T polymorphism and the clinical presentation of Uygur IgA nephropathy patients in XinJiang

• Published in: Asian Pacific journal of allergy and immunology Vol. 29; no. 3; p. 236
• Main Authors: Chen, Lu, Zhu, Kaichun, Zhao, Hongjuan, Ji, Jiani, Ge Mu, Liu, Weili, Xu, Gang, Liu, Xiaocheng
• Format: Journal Article
• Language: English
• Published: Bangkok The Allergy and Immunology Society 01.09.2011
• ISSN: 0125-877X

Objective: To investigate the relationship between T cell receptor alpha chain constant gene (TCRCα) -560 C /T polymorphism and the clinical presentation of Uygur IgA Nephropathy patients in XinJiang. Methods: TCRCα -560 C/T genotypes were determined by PCR-RFLP in 300 Chinese Uygur IgAN patients and 600 healthy Chinese Uygur control subjects. All subjects were classified, based on their genotype, into TT, CT and CC groups and their corresponding clinical presentation was analyzed. Results: No significant difference was observed in the frequency of CC/CT/TT genotypes in patients and control subjects (χ 2 =0.904 , P =0.636). However, the incidence of intermittent microscopic hematuria and proteinuria is significantly higher in patients with CT genotype than CC and TT genotypes (χ 2 =33.978, P <0.05). Conclusion: TCRCα-560 C / T gene polymer-phism may be associated with the occurrence of intermittent microscopic hematuria and proteinuria in Chinese Uygur IgAN patients.