DEPTOR ubiquitination and destruction by SCF^sup [Beta]-TrCP

β-Transducin repeats-containing protein (β-TrCP) is the substrate recognition subunit of the SCF (SKP1, CUL1, and F-box protein)-type E3 ubiquitin ligase complex. SCF... ubiquitinates specifically phosphorylated substrates to promote their subsequent destruction by the 26S proteasome and plays a cri...

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Bibliographic Details
Published inAmerican journal of physiology: endocrinology and metabolism Vol. 303; no. 2; p. E163
Main Authors Wang, Zhiwei, Zhong, Jiateng, Gao, Daming, Inuzuka, Hiroyuki, Liu, Pengda, Wei, Wenyi
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 15.07.2012
Subjects
Cell growth
Disease
Inhibitor drugs
Phosphorylation
Physiology
Proteins
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Summary:β-Transducin repeats-containing protein (β-TrCP) is the substrate recognition subunit of the SCF (SKP1, CUL1, and F-box protein)-type E3 ubiquitin ligase complex. SCF... ubiquitinates specifically phosphorylated substrates to promote their subsequent destruction by the 26S proteasome and plays a critical role in various human diseases including tumorigenesis. We and others (Duan S et al. Mol Cell 44: 317-324, 2011; Gao D et al. Mol Cell 44: 290-303, 2011; Zhao Y et al. Mol Cell 44: 304-316, 2011) recently reported that SCF... regulates cell growth and autophagy by controlling the ubiquitination and destruction of DEPTOR, an endogenous mammalian target of rapamycin inhibitor, in a phosphorylation-dependent manner. In this review, we discuss β-TrCP's new downstream substrate, DEPTOR, as well as summarize the novel functional aspects of β-TrCP in controlling cell growth and regulating autophagy, in part through governing the stability of DEPTOR. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0193-1849
1522-1555