A case of hemoglobin Hiroshima ([beta]146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA^sub 1c

Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA^sub 1c^ level. The presence of an abnormal hemoglobin mol...

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Published inInternational journal of hematology Vol. 95; no. 6; p. 697
Main Authors Nishimori, Hisakazu, Harano, Keiko, Wada, Hideho, Takano, Satoshi, Fukuda, Shinji, Takehara, Yukihito, Matsumoto, Hiroshi, Kumagai, Isao, Tanimoto, Mitsune, Takeda, Sho
Format Journal Article
LanguageEnglish
Published Tokyo Springer Nature B.V 01.06.2012
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Summary:Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA^sub 1c^ level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine [arrow right] aspartic acid). Caution should be exercised when diagnosing erythremia.[PUBLICATION ABSTRACT]
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-012-1066-1