Massive Pulmonary Embolism with Mobile Right Atrial Thrombus in a Pregnant Patient Using Valproic Acid/Valproik Asit Kullanan Bir Hamilede Sag Atriyumdaki Mobil Trombusun Neden Oldugu Masif Pulmoner Emboli

Pulmonary embolism is a life threatening condition. Pregnancy is among the risk factors of pulmonary embolism. There is reluctance about using thrombolytics s during pregnancy due to potential teratogenic effects. Valproic acid is one of the most commonly used antiepileptic agents, hovewer, its use...

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Bibliographic Details
Published inEurasian journal of emergency medicine Vol. 11; no. 1; p. 52
Main Authors Soydinç, Hatice Ender, Yüce, Murat, Sari, Emine, Yavuz, Sema, Sari, Ibrahim, Davutoglu, Vedat, Yigiter, Remzi, Akçay, Murat
Format Journal Article
LanguageEnglish
Published Ankara Galenos Publishing House 01.03.2012
Subjects
Emergency medical care
Medical treatment
Pregnancy
Thrombolytic drugs
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Summary:Pulmonary embolism is a life threatening condition. Pregnancy is among the risk factors of pulmonary embolism. There is reluctance about using thrombolytics s during pregnancy due to potential teratogenic effects. Valproic acid is one of the most commonly used antiepileptic agents, hovewer, its use during pregnancy is controversial because of the teratogenic potential. Among adverse effects of valproic acid use, elevated liver enzymes, thrombocytopenia have been reported. Moreover, product literature warns that pregnant women using valproic acid should be monitored for low fibrinogen and platelets and the potential for bleeding. The present case report describes successful treatment of a massive pulmonary embolism with tissue plasminogen activator (t-PA), caused by a mobile right atrial thrombus in a 30-year-old first trimester pregnant women using valproic acid. This has not been reported previously. During follow-ups, she was free of any signs or symptoms and gave birth to a baby by spontaneous vaginal delivery. The baby was completely healthy without any problem or deformity. [PUBLICATION ABSTRACT]
ISSN:2149-5807
2149-6048