ANTIDEPRESSANT ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF FRUITS OF MOMORDICA CYMBALARIA HOOK. F IN ANIMAL MODELS

The objective of the present study was to evaluate the antidepressant activity of hydro-alcoholic extract of fruits of Momordica cymbalaria Hook. F. Depression is the most common feature and it may range from a very mild condition to even severe depression which is called as psychotic depression. Fu...

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Bibliographic Details
Published inInternational journal of pharmacology and biological sciences Vol. 6; no. 1; p. 1
Main Authors Daripelli, Sai Vishal, Vishwanath, J, Swamy, Vrushabendra B M, Reddy, Anil Kumar P
Format Journal Article
LanguageEnglish
Published Jalgaon Advances in Pharmacology and Toxicology (APT Journals) 01.04.2012
Subjects
Animals
Antidepressants
Behavior
Drug dosages
Fruits
Mortality
Rodents
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Summary:The objective of the present study was to evaluate the antidepressant activity of hydro-alcoholic extract of fruits of Momordica cymbalaria Hook. F. Depression is the most common feature and it may range from a very mild condition to even severe depression which is called as psychotic depression. Furthermore, it is difficult to predict which patient will respond to any given treatment. In the traditional systems of medicine, many plants and formulations have been used to treat depression for thousands of years. In our present study we have selected behavioral despair models namely forced swimming and tail suspension tests. The main findings of present investigations suggest that the above extract posses antidepressant activity in mice forced swim test, tail suspension test and locomotor activity in rats. Hydro-alcoholic extract (HAEMC) was prepared from fruits of Momordica cymbalaria Hook. F. In the present study, the antidepressant effect of HAEMC-1(200mg/kg), HAEMC-2(400mg/kg) and HAEMC-3(600mg/kg) was examined using two behavioral models, the forced swim test (FST) and tail suspension test (TST) in mice. Duration of immobility was noted in both the models. Locomotor activity was also assessed in open field test. In our study, both imipramine and HAEMC significantly reduced the duration of immobility in both experimental models as compared to the animals in the control group. The antidepressant activity of HAEMC was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of HAEMC as an adjuvant in the treatment of depression. [PUBLICATION ABSTRACT]
ISSN:0973-6808