Effect of dehydroepiandrosterone sulfate on aldosterone level during stress exposures: role of [mu]-opioid receptors

• Published in: Bulletin of experimental biology and medicine Vol. 152; no. 6; p. 696
• Main Authors: Obut, T A, Saryg, S K, Ovsukova, M V, Dementeva, T U, Obut, E T, Erdinieva, T A
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.04.2012
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1609-8

Dehydroepiandrosterone sulfate (DHEAS, 30 mg/kg) blocks stress-induced elevation of aldosterone concentration in rats subjected to repeated stress. Administration of DHEAS together with opioid receptor antagonist naltrexone in a dose of 0.1 mg/kg, i.e. the dose that selectively blocks μ-opioid receptors, abolished this blocking effect of DHEAS, which suggests that it is mediated by μ-opioid receptors. Under conditions of cold exposure, DHEAS exhibits the aldosterone-blocking effect even after single presentation of the stress factor. However, this effect is realized not via μ-opioid receptors, which attests to differences in the regulatory mechanisms depending on the nature of the external factor.[PUBLICATION ABSTRACT]